Macromolecular Biophysics Core

Overview of Services

The Macromolecular Biophysics (MacBio) Core offers access and training to a range of instruments that can be used to biophysically characterize biological macromolecules. These resources were previously available only to a few labs at the SOM, but the core now centralizes them and provides training to all JHU researchers. Some of the available instruments include Biacore 8K (SPR), Refeyn Two-MP Mass Photometer (MP), NanoTemper NT-11.5 for Micro-scale Thermophoresis (MST), Agilent HPLC coupled to Wyat's Heleos II and T-REX detectors  for Size-Exclusion-Multiwavelength Light Scattering (SEC-MALS), Malvern's VP-ITC and ITC200 for Isothermal Titration calorimetry (ITC),  capillary DSC for Differential Scanning Calorimetry. The MacBio Core also offers facilities and instruments for macromolecular crystallization, such as a Mosquito-LC crystallization robot and a RockImager automatic imaging and constant temperature room. These resources are overseen to ensure that inexperienced users receive proper training and guidance.

Leadership

Cynthia Wolberger

Location and hours of operation

Hours      Location

10:00 AM - 4 PM Monday to Friday

     725 N wolfe st  Wood Basic Science Building 709
     Baltimore, MD,21205

Links and Resources

  1. https://biophysics.med.jhmi.edu/macbio/

Contacts

Name Role Phone Email Location
Mario A Bianchet, PhD
Contractor
 
443 5917583
 
primacoremanagement@gmail.com
 

 

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